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KMID : 0385219980080020008
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Korean Journal of Gerontology
1998 Volume.8 No. 2 p.8 ~ p.13
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Oryza sativa L. subsp. hsien Ting Inhibits Mast Cell-Mediated Anaphylaxis in Mice and Rats
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Chung Jong-Gab
Kim Hyung-Min
Kim Chang-Young
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Abstract
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As part of our continuing search for biologically active antiallergic agents from medicinal source, Oryza sativa L. subsp. hsien Ting (OSHT) was analyzed. OSHT has been used for treatment of various allergic diseases in Korea. OSHT (0.001∼1.0 g/kg) inhibited systemic anaphylaxis induced by compound 48/80 in mice dose-dependently. When OSHT was pretreated at concentrations ranging from 0.001 to 1.0 g/kg, the serum histamine levels of mice were reduced in a dose-dependent manner. The skin of rat is a useful site for studying local anaphylaxis. Anti-dinitrophenyl(DNP) IgE induces passive cutaneous anaphylaxis(PCA) reaction through degranulation of mast cells. OSHT also inhibited PCA reactions activated by anti-DNP IgE. Moreover, OSHT dose-dependently inhibited the histamine release from rat peritoneal mast cells activated by compound 48/80 or anti-DNP IgE. These results indicate that OSHT inhibits mast cell-mediated anaphylaxis.
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KEYWORD
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Oryza sativa L. subsp. hsien Ting, Anaphylaxis, Histamine, Rat peritoneal Mast cells
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